Dapagliflozin reduces pulmonary vascular damage and susceptibility to atrial fibrillation in right heart disease.

ABSTRACT:

Aims

Sodium-glucose cotransporter 2 inhibitors (SGLT2is) have made considerable progress in the field of heart failure, but their application in arrhythmia remains to be in-depth. Right heart disease (RHD) often leads to right heart dysfunction and is associated with atrial fibrillation (AF). Here, we explored the possible electrophysiologic effect of dapagliflozin (a type of SGLT2is) in the development of AF in rats with RHD.

Methods and results

Rats in the experimental group were intraperitoneally injected with a single dose of 60 mg/kg monocrotaline (MCT group, n = 32) on the first day of the experiment, whereas rats in the control group were injected with vehicle (CTL group, n = 32). Rats in the treatment subgroup were treated with dapagliflozin solution orally (MCT + DA

SUBMITTER: Dai C 

PROVIDER: S-EPMC9871681 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature