Frailty interferes with the guideline-directed medical therapy in heart failure patients with reduced ejection fraction.

ABSTRACT:

Aims

Guideline-directed medical therapy (GDMT) in patients with heart failure with reduced ejection fraction (HFrEF) is recommended in clinical guidelines, but elderly patients have not fully received GDMT in the clinical situation. The aim of this study was to determine the clinical characteristics of patients who have not received GDMT and the association between implementation of GDMT at discharge and physical frailty in patients with HFrEF who were hospitalized for acute decompensated heart failure (ADHF).

Methods and results

This study was a cross-sectional study with a retrospective analysis of the Kochi YOSACOI study, a prospective multicentre observational study that enrolled 1061 patients hospitalized for ADHF from May 2017 to December 2019 in Japan. Of 339 patients

SUBMITTER: Hamada T 

PROVIDER: S-EPMC9871689 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature