Use of serial changes in biomarkers vs. baseline levels to predict left ventricular remodelling after STEMI.

ABSTRACT:

Aims

Cellular communication network factor 1 (CCN1) is an independent predictor of MACE after ACS and elevated levels correlated with infarct size after STEMI. We compared the prognostic accuracy of baseline levels of CCN1, NT-proBNP, hsTnT, and ST2 and changes in levels over time to predict the development of structural and functional alterations typical of LV remodelling.

Methods

Serial 3-T cMRI scans were performed to determine LVEF, LVEDV, LVESV, infarct size, and relative infarct size, which were correlated with serial measurements of the four biomarkers. The prognostic significance of these biomarkers was assessed by multiple logistic regression analysis by examining their performance in predicting dichotomized cardiac MRI values 12 months after STEMI based on their me

SUBMITTER: Klingenberg R 

PROVIDER: S-EPMC9871716 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature