Novel Fat Taste Receptor Agonists Curtail Progressive Weight Gain in Obese Male Mice.

ABSTRACT:

Background & aims

The spontaneous preference for dietary lipids is principally regulated by 2 lingual fat taste receptors, CD36 and GPR120. Obese animals and most of human subjects exhibit low orosensory perception of dietary fat because of malfunctioning of these taste receptors. Our aim was to target the 2 fat taste receptors by newly synthesized high affinity fatty acid agonists to decrease fat-rich food intake and obesity.

Methods

We synthesized 2 fat taste receptor agonists (FTA), NKS-3 (CD36 agonist) and NKS-5 (CD36 and GPR120 agonist). We determined their molecular dynamic interactions with fat taste receptors and the effect on Ca²⁺ signaling in mouse and human taste bud cells (TBC). In C57Bl/6 male mice, we assessed their gustatory perception and effects o

SUBMITTER: Khan AS 

PROVIDER: S-EPMC9871744 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature