Cerebral regional tissue Oxygen Saturation to Guide Oxygen Delivery in preterm neonates during immediate transition after birth (COSGOD III): multicentre randomised phase 3 clinical trial.

ABSTRACT:

Objective

To investigate whether monitoring of cerebral tissue oxygen saturation using near infrared spectroscopy in addition to routine monitoring combined with defined treatment guidelines during immediate transition and resuscitation increases survival without cerebral injury of premature infants compared with standard care alone.

Design

Multicentre, multinational, randomised controlled phase 3 trial.

Setting

11 tertiary neonatal intensive care units in six countries in Europe and in Canada.

Participants

1121 pregnant women (<32 weeks' gestation) were screened prenatally. The primary outcome was analysed in 607 of 655 randomised preterm neonates: 304 neonates in the near infrared spectroscopy group and 303 in the control group.

Intervention

Preterm ne

SUBMITTER: Pichler G 

PROVIDER: S-EPMC9871806 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature