Dimorphic glioblastoma with glial and epithelioid phenotypes: Clonal evolution and immune selection.

ABSTRACT:

Purpose

Epithelioid glioblastoma is an unusual histologic variant of malignant glioma. The present study investigates both the genomic and transcriptomic determinants that may promote the development of this tumor.

Methods

Whole-exome sequencing (WES) and whole-transcriptome sequencing (WTS) were performed on an epithelioid glioblastoma, along with a specific bioinformatic pipeline to generate electronic karyotyping and investigate the tumor immune microenvironment. Microdissected sections containing typical glioblastoma features and epithelioid morphology were analyzed separately using the same methodologies.

Results

An epithelioid glioblastoma, with immunopositivity for GFAP, Olig-2, and ATRX but negative for IDH-1 and p53, was identified. The tumor cell content fro

SUBMITTER: Mondia MWL 

PROVIDER: S-EPMC9871816 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature