Differential patterns of default mode network activity associated with negative and positive rumination in bipolar disorder.

ABSTRACT:

Background

Patients with bipolar disorder (BD) engage in both negative and positive rumination, defined as maladaptive self-focused thinking, and this tendency predicts depressive and manic episodes, respectively. Prior research in patients with major depression implicates regions of the default mode network (DMN) consistent with the self-focused nature of rumination. Little is known about the neural correlates of rumination in bipolar disorder.

Methods

Fifteen euthymic patients with BD (twelve with Type I) and 17 healthy controls (HC) performed negative and positive rumination induction tasks, as well as a distraction task, followed by a self-related trait judgment task while undergoing functional magnetic resonance imaging (fMRI). Participants also underwent resting state

SUBMITTER: Ghaznavi S 

PROVIDER: S-EPMC9871916 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature