T cell activation profiles can distinguish gram negative/positive bacterial sepsis and are associated with ICU discharge.

ABSTRACT:

Introduction

Sepsis is a life-threatening complication resulting from a dysregulated host response to a serious infection, of which bacteria are the most common cause. A rapid differentiation of the gram negative (G^-)/gram positive (G⁺) pathogens facilitates antibiotic treatment, which in turn improves patients' survival.

Methods

We performed a prospective, observational study of adult patients in intensive care unit (ICU) unit and underwent the analysis of peripheral blood lymphocyte subsets, cytokines and other clinical indexes. The enrolled 94 patients were divided into no infection group (n=28) and bacterial sepsis group (n=66), and the latter group was subdivided into G^- (n=46) and G⁺ (n=20) sepsis subgroups.

Results

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SUBMITTER: Huang C 

PROVIDER: S-EPMC9871918 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature