Comprehensive analysis of alfa defensin expression and prognosis in human colorectal cancer.

ABSTRACT:

Introduction

Colorectal cancer (CRC) is a serious threat to human health. Screening new biomarkers can provide basis for improving the prognosis and individualized treatment of CRC. Although some members of the defensin family were found increased in pancreatic cancer and CRC, their exact function and clinical significance remain unclear.

Methods

In this study, the expression, correlation, mutation, and functional enrichment of several defensin family members in pancreatic cancer and CRC were analyzed using tumor public databases and verified in several patients.

Results

Results showed no significant correlation between the expression levels of DEFA1-4 and CRC. The expression levels of DEFA5 and DEFA6 significantly increased in CRC tissues compared with those in norma

SUBMITTER: Zhao X 

PROVIDER: S-EPMC9872005 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature