Perinatal Western-style diet alters serotonergic neurons in the macaque raphe nuclei.

ABSTRACT:

Introduction

The neurotransmitter serotonin is a key regulator of neurotransmission, mood, and behavior and is essential in neurodevelopment. Dysfunction in this important neurotransmitter system is connected to behavioral disorders such as depression and anxiety. We have previously shown that the developing serotonin system is sensitive to perinatal exposure to Western-style diet (WSD).

Methods

To advance our hypothesis that perinatal WSD has a long-term impact on the serotonergic system, we designed a fluorescent immunohistochemistry experiment using antibodies against tryptophan hydroxylase 2 (TPH2) and vesicular glutamate transporter 3 (VGLUT3) to probe protein expression in the raphe subnuclei in 13-month-old Japanese macaques (Macaca fuscata; n = 22). VGL

SUBMITTER: Dunn GA 

PROVIDER: S-EPMC9872117 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature