Effects of vitamin K supplementation on vascular calcification in chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

There is conflicting data on the effect of vitamin K supplementation against vascular calcification in chronic kidney disease (CKD). We aimed to summarize current evidence from randomized controlled trials (RCTs) to determine whether vitamin K supplementation in CKD could attenuate vascular calcification.

Methods

A systematic search was performed in MEDLINE, EMBASE, and Cochrane Central Library. RCTs assessing the effect of vitamin K supplementation on vascular calcification in CKD and reported measures relevant to vascular calcification were eligible for inclusion. Effect outcomes are changes of biochemical and imaging measures of vascular calcification, as well as vascular elasticity reflected by pulse wave velocity (PWV). Safety outcomes included any adverse ev

SUBMITTER: Geng C 

PROVIDER: S-EPMC9872197 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature