Ontology highlight
ABSTRACT:
SUBMITTER: Storck SE
PROVIDER: S-EPMC9872255 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Storck Steffen E SE Hartz Anika M S AMS Pietrzik Claus U CU
Handbook of experimental pharmacology 20220101
The accumulation of neurotoxic amyloid-beta (Aβ) in the brain is one of the characteristic hallmarks of Alzheimer's disease (AD). Aβ-peptide brain homeostasis is governed by its production and various clearance mechanisms. The blood-brain barrier provides a large surface area for influx and efflux mechanisms into and out of the brain. Different transporters and receptors have been implicated to play crucial roles in Aβ clearance from brain. Besides Aβ transport, the blood-brain barrier tightly r ...[more]