C/EBPβ expression decreases in cervical cancer and leads to tumorigenesis.

ABSTRACT:

Background

Cervical cancer is currently estimated to be the fourth most common cancer among women worldwide and the leading cause of cancer-related deaths in some of the world's poorest countries. C/EBPβ has tumor suppressor effects because it is necessary for oncogene-induced senescence. However, C/EBPβ also has an oncogenic role. The specific role of C/EBPβ in cervical cancer as a tumor suppressor or oncoprotein is unclear.

Objective

To explore the role of the C/EBPβ protein in cervical tumorigenesis and progression.

Methods

Quantitative RT-PCR was used to analyze C/EBPβ (15 cervical cancer tissue samples and 15 corresponding normal cervical tissue samples), miR-661, and MTA1 mRNA expression in clinical samples (10 cervical cancer tissue samples and 10 corresponding

SUBMITTER: Long H 

PROVIDER: S-EPMC9872280 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature