FAM83B promotes the invasion of primary lung adenocarcinoma via PI3K/AKT/NF-κB pathway.

ABSTRACT:

Objects

The family with sequence similarity 83B (FAM83B) is one of the markers for poor prognosis in several carcinomas, but the expression and the mechanism resulted in malignant phenotype in lung adenocarcinoma (LUAD) remain to be elucidated.

Methods

 Data of RNA-seq in LUAD were downloaded from the cancer genome atlas (TCGA) database for differential expression and survival analysis, and immunohistochemistry was employed to analyze the protein expression of FAM83B in 126 cases of primary LUAD. The LUAD cell lines were collected for the detection of the effects on migration and invasion. Then, western blot was performed to measure the expression of tissue inhibitor of metalloproteinase (TIMP)-1 and activation of PI3K/AKT/NF-κB pathway.

Results

FAM83B was overexpress

SUBMITTER: Zhang J 

PROVIDER: S-EPMC9872310 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature