Maternal periconceptional environmental exposure and offspring with congenital heart disease: a case-control study in Guangzhou, China.

ABSTRACT:

Background

Congenital heart defects (CHDs) are a major global health problem, yet their crucial environmental risk factors are still unclear. We aimed to explore the associations between maternal periconceptional environmental exposures and all CHDs, isolated and multiple CHDs and CHDs subtypes.

Method

A case-control study including 675 infants with CHDs and 1545 healthy controls was conducted. Participating mothers who delivered in Guangzhou from October 2019 to November 2021 were recruited. To examine the independent associations between maternal periconceptional environmental exposure and offspring with CHDs, we calculated odds ratios (ORs) and 95% confidence intervals (CIs) using multivariable logistic regression model.

Results

Maternal exposure to living near mai

SUBMITTER: Xiao D 

PROVIDER: S-EPMC9872400 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature