Circulating levels of endotrophin and cross-linked type III collagen reflect liver fibrosis in people with HIV.

ABSTRACT:

Background and aims

Liver-associated complications still frequently lead to mortality in people with HIV (PWH), even though combined antiretroviral treatment (cART) has significantly improved overall survival. The quantification of circulating collagen fragments released during collagen formation and degradation correlate with the turnover of extracellular matrix (ECM) in liver disease. Here, we analysed the levels of ECM turnover markers PC3X, PRO-C5, and PRO-C6 in PWH and correlated these with hepatic fibrosis and steatosis.

Methods

This monocentre, retrospective study included 141 PWH. Liver stiffness and liver fat content were determined using transient elastography (Fibroscan) with integrated CAP function. Serum levels of formation of cross-linked type III collagen (PC3

SUBMITTER: Dold L 

PROVIDER: S-EPMC9872428 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature