Starch intake, amylase gene copy number variation, plasma proteins, and risk of cardiovascular disease and mortality.

ABSTRACT:

Background

Salivary amylase, encoded by the AMY1 gene, initiate the digestion of starch. Whether starch intake or AMY1 copy number is related to disease risk is currently rather unknown. The aim was to investigate the association between starch intake and AMY1 copy number and risk of cardiovascular disease (CVD) and mortality and whether there is an interaction. In addition, we aim to identify CVD-related plasma proteins associated with starch intake and AMY1 copy number.

Methods

This prospective cohort study used data from 21,268 participants from the Malmö Diet and Cancer Study. Dietary data were collected through a modified diet history method and incident CVD and mortality were ascertained through registers. AMY1 gene copy number was determined by droplet digital polymer

SUBMITTER: Li H 

PROVIDER: S-EPMC9872432 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature