School-age outcomes among IVF-conceived children: A population-wide cohort study.

ABSTRACT:

Background

In vitro fertilisation (IVF) is a common mode of conception. Understanding the long-term implications for these children is important. The aim of this study was to determine the causal effect of IVF conception on primary school-age childhood developmental and educational outcomes, compared with outcomes following spontaneous conception.

Methods and findings

Causal inference methods were used to analyse observational data in a way that emulates a target randomised clinical trial. The study cohort comprised statewide linked maternal and childhood administrative data. Participants included singleton infants conceived spontaneously or via IVF, born in Victoria, Australia between 2005 and 2014 and who had school-age developmental and educational outcomes assessed. The

SUBMITTER: Kennedy AL 

PROVIDER: S-EPMC9873192 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature