Investigation of white matter and grey matter alteration in the monkey brain following ischemic stroke by using diffusion tensor imaging.

ABSTRACT:

Background

Investigation of stroke lesion has mostly focused on grey matter (GM) in previous studies and white matter (WM) degeneration during acute stroke is understudied. In the present study, monkeys were utilized to investigate the alterations of GM and WM in the brain following ischemic occlusion using diffusion tensor imaging (DTI).

Methods

Permanent middle cerebral artery occlusion (pMCAO) was induced in rhesus monkeys (n=6) with an interventional approach. Serial DTI was conducted on a clinical 3T in the hyperacute phase (2-6 hours), 48, and 96 hours post occlusion. Regions of interest in GM and WM of lesion areas were selected for data analysis.

Results

Mean diffusivity (MD), radial diffusivity (RD), and axial Diffusivity (AD) in WM decreased substantially du

SUBMITTER: Li CX 

PROVIDER: S-EPMC9873195 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature