Long-term follow-up of an IgA nephropathy cohort: outcomes and risk factors.

ABSTRACT:

Aim

IgA nephropathy (IgAN), the most common glomerulopathy worldwide and in Uruguay, raised treatment controversies. The study aimed to analyze long-term IgAN outcomes and treatment.

Methods

A retrospective analysis of a Uruguayan IgAN cohort, enrolled between 1985 and 2009 and followed up until 2020, was performed. The Ethics Committee approved the study. The inclusion criteria were (a) biopsy-proven IgAN; (b) age ≥12 years; and (c) available clinical, histologic, and treatment data. The patients were divided into two groups, with immunosuppressive (IS) or without (NoIS) treatment. Outcomes (end-stage kidney disease/kidney replacement therapy [ESKD/KRT] or all-cause death) were obtained from mandatory national registries.

Results

The study population included 241 pat

SUBMITTER: Gadola L 

PROVIDER: S-EPMC9873278 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature