Tissue mechanics modulate PCNP expression in oral squamous cell carcinomas with different differentiation.

ABSTRACT:

Background

PEST-containing nuclear protein (PCNP), a novel zinc finger protein, participates in cell cycle regulation. Previous studies have confirmed that PCNP plays a role in mediating cellular development and invasion in a variety of cancer types. However, the relationship between PCNP expression and the occurrence and development of oral squamous cell carcinoma (OSCC) requires further exploration. In this study, we used biological atomic force microscopy to examine the histomorphological and mechanical properties of OSCC to explore the relationship between PCNP expression and differentiation of OSCC.

Methods

Seventy-seven OSCC samples with varying degrees of differentiation were selected for hematoxylin and eosin staining, immunohistochemistry, and cellular mechanical me

SUBMITTER: Zhang L 

PROVIDER: S-EPMC9873348 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature