Cadmium-mediated pancreatic islet transcriptome changes in mice and cultured mouse islets.

ABSTRACT: Type II diabetes mellitus (T2DM) is a multifactorial disease process that is characterized by insulin resistance and impairment of insulin-producing pancreatic islets. There is evidence that environmental exposure to cadmium contributes to the development of T2DM. The presence of cadmium in human islets from the general population and the uptake of cadmium in β-cells have been reported. To identify cadmium-mediated changes in gene expression and molecular regulatory networks in pancreatic islets, we performed next-generation RNA-Sequencing (RNA-Seq) in islets following either in vivo (1 mM CdCl₂ in drinking water) or ex-vivo (0.5 μM CdCl₂) exposure. Both exposure regiments resulted in islet cadmium concentrations that are comparable to those found in human islets from

SUBMITTER: Wong WPS 

PROVIDER: S-EPMC9873403 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature