Human leukocyte antigen allele and haplotype frequencies in Singapore bone marrow donors and cord blood units.

ABSTRACT: We describe the allele and haplotype frequencies seen in a volunteer unrelated bone marrow donor registry, a public cord blood bank, and donor/recipient samples processed by the Health Sciences Authority (HSA) in Singapore. Historical human leukocyte antigen (HLA) typing reports were anonymized and combined. They were checked for HLA typing nomenclature discrepancies or ambiguities using the HLA-net UNIFORMATE tool, and for analysis, the validated data were subsequently separated into Chinese, Malay, Indian, and "Others," according to the race classification system used in Singapore. Individual ethnic allele and haplotype frequencies were calculated with the HLA-net GENE[RATE] pipeline using basic statistics. The Basic Statistics Tool of HLA-net was used to estimate haplotype frequency usi

SUBMITTER: Yu-Jin AN 

PROVIDER: S-EPMC9873421 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature