Optimization of the radiation dosimetry protocol in Lutetium-177-PSMA therapy: toward clinical implementation.

ABSTRACT:

Background

Dosimetry in [¹⁷⁷Lu]Lu-PSMA therapy is a valuable tool to assess treatment efficacy and toxicity. This study aims to develop a clinically implementable protocol to determine the absorbed dose in organs and tumor lesions after [¹⁷⁷Lu]Lu-PSMA-617 therapy, by reducing the imaging time points and utilizing population-based kinetics with a single scan, with evaluation of its influence on the uncertainty in absorbed dose.

Methods

Ten patients with metastatic hormone-sensitive prostate cancer received two cycles of [¹⁷⁷Lu]Lu-PSMA-617. Post-treatment imaging was performed at 1 h, 24 h, 48 h, 72 h and 168 h, consisting of three-bed positions SPECT/CT and a whole-body planar scan. Five-time point SPECT dosimetry was performed for lesions and

SUBMITTER: Peters SMB 

PROVIDER: S-EPMC9873880 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature