A temporal classifier predicts histopathology state and parses acute-chronic phasing in inflammatory bowel disease patients.

ABSTRACT: Previous studies have conducted time course characterization of murine colitis models through transcriptional profiling of differential expression. We characterize the transcriptional landscape of acute and chronic models of dextran sodium sulfate (DSS) and adoptive transfer (AT) colitis to derive temporal gene expression and splicing signatures in blood and colonic tissue in order to capture dynamics of colitis remission and relapse. We identify sub networks of patient-derived causal networks that are enriched in these temporal signatures to distinguish acute and chronic disease components within the broader molecular landscape of IBD. The interaction between the DSS phenotype and chronological time-point naturally defines parsimonious temporal gene expression and splicing signatures asso

SUBMITTER: Peters LA 

PROVIDER: S-EPMC9873918 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature