Genetic variation in the human olfactory receptor OR5AN1 associates with the perception of musks.

ABSTRACT: Humans have significant individual variations in odor perception, derived from their experience or sometimes from differences in the olfactory receptor (OR) gene repertoire. In several cases, the genetic variation of a single OR affects the perception of its cognate odor ligand. Musks are widely used for fragrance and are known to demonstrate specific anosmia. It, however, remains to be elucidated whether the OR polymorphism contributes to individual variations in musk odor perception. Previous studies reported that responses of the human musk receptor OR5AN1 to a variety of musks in vitro correlated well with perceptual sensitivity to those odors in humans and that the mouse ortholog, Olfr1440 (MOR215-1), plays a critical role in muscone perception. Here, we took advantage of genetic vari

SUBMITTER: Sato-Akuhara N 

PROVIDER: S-EPMC9874024 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature