Animal Models of Relevance to the Schizophrenia Prodrome.

ABSTRACT: Patients with schizophrenia often undergo a prodromal phase prior to diagnosis. Given the absence of significant therapeutic improvements, attention has recently shifted to the possibility of intervention during this early stage to delay or diminish symptom severity or even prevent onset. Unfortunately, the 20 or so trials of intervention to date have not been successful in either preventing onset or improving long-term outcomes in subjects who are at risk of developing schizophrenia. One reason may be that the biological pathways an effective intervention must target are not static. The prodromal phase typically occurs during late adolescence, a period during which a number of brain circuits and structures are still maturing. We propose that developing a deeper understanding of which circ

SUBMITTER: Petty A 

PROVIDER: S-EPMC9874082 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature