Identification and evaluation of midbrain specific longevity-related genes in exceptionally long-lived but healthy mice.

ABSTRACT: Brain aging is a complex biological process that is affected by both genetic background and environment. The transcriptomic analysis of aged human and rodent brains has been applied to identify age-associated molecular and cellular processes for which intervention could possibly restore declining brain functions induced by aging. However, whether these age-associated genetic alterations are indeed involved in the healthy aging of the brain remains unclear. We herein characterized a naturally occurring, extremely long-lived (34 months of age) but healthy mouse group retaining well-preserved motor functions. Strikingly, these long-lived mice maintained tyrosine hydroxylase expression and dopaminergic fiber densities, even in the presence of persistent neuroinflammation and expression of agin

SUBMITTER: Kim H 

PROVIDER: S-EPMC9874112 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature