Multiple-model machine learning identifies potential functional genes in dilated cardiomyopathy.

ABSTRACT:

Introduction

Machine learning (ML) has gained intensive popularity in various fields, such as disease diagnosis in healthcare. However, it has limitation for single algorithm to explore the diagnosing value of dilated cardiomyopathy (DCM). We aim to develop a novel overall normalized sum weight of multiple-model MLs to assess the diagnosing value in DCM.

Methods

Gene expression data were selected from previously published databases (six sets of eligible microarrays, 386 samples) with eligible criteria. Two sets of microarrays were used as training; the others were studied in the testing sets (ratio 5:1). Totally, we identified 20 differently expressed genes (DEGs) between DCM and control individuals (7 upregulated and 13 down-regulated).

Results

We developed six class

SUBMITTER: Zhang L 

PROVIDER: S-EPMC9874116 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature