The causal association between bone mineral density and risk of osteoarthritis: A Mendelian randomization study.

ABSTRACT:

Objectives

The causal direction and magnitude of the association between total body bone mineral density (TB-BMD) and osteoarthritis (OA) risk is uncertain owing to the susceptibility of observational studies to confounding and reverse causation. The study aimed to explore the relationships between TB-BMD concentration and OA using Mendelian randomization (MR).

Methods

In this study, we used two-sample MR to obtain unconfounded estimates of the effect of TB-BMD on hip and knee OA. Single nucleotide polymorphisms (SNPs) strongly associated with TB-BMD in a large genome-wide association study (GWAS) were identified and selected as instrumental variables (IVs). In addition to the main analysis using inverse-variance weighted (IVW) method, we applied 2 additional methods to cont

SUBMITTER: Jiang L 

PROVIDER: S-EPMC9874138 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature