Nasal administration of mesenchymal stem cells prevents accelerated age-related tauopathy after chemotherapy in mice.

ABSTRACT:

Background

There is increasing concern that cancer and cancer treatment accelerate aging and the associated cognitive decline. We showed recently that treatment of 9-month-old male mice with cisplatin causes cognitive deficits that are associated with formation of tau deposits in the hippocampus. Here we explored the capacity of mesenchymal stem cells (MSC) given via the nose to prevent age-related brain tau deposits. Moreover, we more closely examined the cellular distribution of this hallmark of accelerated brain aging in response to treatment of 9-month-old female and male mice with cisplatin.

Results

We show that cisplatin induces tau deposits in the entorhinal cortex and hippocampus in both sexes. The tau deposits colocalize with syndecan-2. Astrocytes surrounding tau d

SUBMITTER: Zamorano M 

PROVIDER: S-EPMC9874182 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature