Fire in the belly: A scoping review of the immunopathological mechanisms of acute pancreatitis.

ABSTRACT:

Introduction

Acute pancreatitis (AP) is characterised by an inflammatory response that in its most severe form can cause a systemic dysregulated immune response and progression to acute multi-organ dysfunction. The pathobiology of the disease is unclear and as a result no targeted, disease-modifying therapies exist. We performed a scoping review of data pertaining to the human immunology of AP to summarise the current field and to identify future research opportunities.

Methods

A scoping review of all clinical studies of AP immunology was performed across multiple databases. Studies were included if they were human studies of AP with an immunological outcome or intervention.

Results

205 studies met the inclusion criteria for the review. Severe AP is characterised by s

SUBMITTER: Venkatesh K 

PROVIDER: S-EPMC9874226 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature