Association of COVID-19 vaccination before conception with maternal thyroid function during early pregnancy: A single-center study in China.

ABSTRACT: Despite the high vaccination coverage, potential COVID-19 vaccine-induced adverse effects, especially in pregnant women, have not been fully characterized. We examined the association between COVID-19 vaccination before conception and maternal thyroid function during early pregnancy. We conducted a retrospective cohort study in Shanghai, China. A total of 6979 pregnant women were included. Vaccine administration was obtained from electronic vaccination records. Serum levels of thyroid hormone were measured by fluorescence and chemiluminescence immunoassays. Among the 6979 included pregnant women, 3470 (49.7%) received at least two doses of an inactivated vaccine. COVID-19 vaccination had a statistically significant association with both maternal serum levels of free thyroxine (FT4) and thy

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC9874602 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature