β-hydroxybutyrate enhances bovine neutrophil adhesion by inhibiting autophagy.

ABSTRACT:

Introduction

Subclinical ketosis (SCK) in dairy cows, a common metabolic disorder during the perinatal period, is accompanied by systemic inflammation and a high concentration of blood β-hydroxybutyrate (BHB). BHB induced adhesion of neutrophils may play a crucial role in the development of systemic inflammation in SCK cows. Autophagy, an intracellular degradation system, regulates the recycling of membrane adhesion molecules and may be involved in BHB regulating adhesion and pro-inflammatory activation of bovine neutrophils. Thus, the objective of this study was to determine the relationship between BHB, autophagy, and neutrophil adhesion.

Results and discussion

Here, elevated abundance of serum amyloid A, haptoglobin, C-reactive protein, interleukin-1β, interleukin-6, and

SUBMITTER: He J 

PROVIDER: S-EPMC9874688 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature