Association of metformin use with fracture risk in type 2 diabetes: A systematic review and meta-analysis of observational studies.

ABSTRACT:

Aims

Increasing evidence suggests that metformin can affect bone metabolism beyond its hypoglycemic effects in diabetic patients. However, the effects of metformin on fracture risk in type 2 diabetes mellitus (T2DM) patients remain unclear. A systematic review and meta-analysis were performed in this study to evaluate the association between metformin application and fracture risk in T2DM patients based on previous studies published until June 2021.

Methods

A systematic search was performed to collect publications on metformin application in T2DM patients based on PubMed, Embase, Cochran, and Web of Science databases. Meta-analysis was performed by using a random-effects model to estimate the summary relative risks (RRs) with 95% confidence intervals (CIs). Subgroup analyses

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9874692 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature