Combined microbiome and metabolome analysis of gut microbiota and metabolite interactions in chronic spontaneous urticaria.

ABSTRACT:

Background

The pathogenesis of chronic spontaneous urticaria (CSU) is unclear, and it turned out to be involved in biological processes, such as autoimmunity, autoallergy, inflammation, and coagulation. The gut microbiota plays an important role in immune and inflammatory diseases. However, the relationship between chronic spontaneous urticaria and the gut microbiota remains unknown.

Methods

The stool and serum samples were taken from 15 CSU patients and 15 normal controls. Changes in the composition of gut microbiota and serum metabolism in CSU patients and normal controls were analyzed by 16S ribosomal RNA (rRNA) gene sequencing and untargeted metabolomics.

Results

The results of 16S rRNA gene sequencing showed that compared with normal controls, CSU patients had in

SUBMITTER: Luo Z 

PROVIDER: S-EPMC9874702 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature