Sperm telomere length as a novel biomarker of male infertility and embryonic development: A systematic review and meta-analysis.

ABSTRACT:

Background

Telomeres have an essential role in maintaining the integrity and stability of the human chromosomal genome and preserving essential DNA biological functions. Several articles have been published on the association of STL with male semen parameters and clinical pregnancy. The results, however, are either inconclusive or inconsistent. Therefore, this meta-analysis aimed to systematically assess the accuracy and clinical value of sperm telomere length (STL) as a new marker for diagnosing male infertility and predicting the quality of embryonic development.

Methods

We performed a comprehensive systematic search for relevant publications in PubMed, the Cochrane Library, Web of Science, Embase, Scopus, and Ovid, from database build to August 2022. All experimental stud

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC9875015 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature