High clinical diagnostic accuracy of combined salivary gland and myocardial metaiodobenzylguanidine scintigraphy in the diagnosis of Parkinson's disease.

ABSTRACT:

Background

Decreased myocardial uptake of ¹³¹I-metaiodobenzylguanidine (MIBG) is known to be an important feature to diagnose Parkinson's disease (PD). However, the diagnosis accuracy of myocardial MIBG scintigraphy alone is often unsatisfying. Recent studies have found that the MIBG uptake of the major salivary glands was reduced in PD patients as well.

Purpose

To evaluate the diagnostic value of major salivary gland MIBG scintigraphy in PD, and explore the potential role of myocardial MIBG scintigraphy combined with salivary gland MIBG scintigraphy in distinguishing PD from non-PD (NPD).

Methods

Thirty-seven subjects were performed with ¹³¹I-MIBG scintigraphy. They were classified into the PD group (N = 18) and the NPD group (N = 

SUBMITTER: Li S 

PROVIDER: S-EPMC9875016 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature