Platinum drugs-related safety profile: The latest five-year analysis from FDA adverse event reporting system data.

ABSTRACT:

Background

With the widespread application of platinum drugs in antitumor therapy, the incidence of platinum drug adverse events (ADEs) is always severe. This study aimed to explore the adverse event signals of Cisplatin, Carboplatin and Oxaliplatin, three widely used platinum-containing drugs, and to provide a reference for rational individualized clinical drug use.

Methods

The adverse event report data of the three platinum drugs from the first quarter of 2017 to the fourth quarter of 2021 were extracted from the FAERS database, and the data mining and risk factors for the relevant reports were carried out using the reporting odds ratio (ROR) method the proportional reporting ratio (PRR)and the comprehensive criteria (MHRA) method.

Results

A total of 1853 effective

SUBMITTER: Feng G 

PROVIDER: S-EPMC9875054 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature