Associations between abnormal spontaneous neural activity and clinical variables, eye movements, and event-related potential indicators in major depressive disorder.

ABSTRACT:

Background

This study aimed to investigate the correlations between abnormal spontaneous neural activity measured with fractional amplitude of low-frequency fluctuations (fALFF) and clinical variables, eye movements, and event-related potential indicators in patients with major depressive disorder (MDD).

Methods

We recruited 42 patients with MDD and 42 healthy controls (HCs) and collected their clinical variables, eye movement, event-related potential, and resting-state functional magnetic resonance imaging (rs-fMRI) data. The fALFF, support vector machine (SVM), and correlation analysis were used to analyze the data.

Results

The results of the study showed that the fALFF values of the sensorimotor network, including the right middle temporal gyrus, right cerebellar C

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC9875062 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature