Construction of a DNA damage repair gene signature for predicting prognosis and immune response in breast cancer.

ABSTRACT: DNA damage repair (DDR) genes are involved in developing breast cancer. Recently, a targeted therapeutic strategy through DNA repair machinery, including PARPi, has initially shown broad development and application prospects in breast cancer therapy. However, few studies that focused on the correlation between the expression level of DNA repair genes, prognosis, and immune response in breast cancer patients have been recently conducted. Herein, we focused on identifying differentially expressed DNA repair genes (DEGs) in breast cancer specimens and normal samples using the Wilcoxon rank-sum test. Biofunction enrichment analysis was performed with DEGs using the R software "cluster Profiler" package. DNA repair genes were involved in multivariate and univariate Cox regression analyses. Afte

SUBMITTER: Chang Y 

PROVIDER: S-EPMC9875088 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature