Serum neurofilament light chain in myasthenia gravis subgroups: An exploratory cohort and case-Control study.

ABSTRACT:

Background

This study aimed to evaluate the association of neurofilament light chain (Nfl) with neuromuscular destruction and disease severity in the serum of patients with myasthenia gravis (MG).

Materials and methods

Sera from 134 patients with MG with varying degrees of disease severity and autoantibody (Abs) status were analyzed and compared to controls in a cross-sectional design. Prospectively, we additionally measured serum NfL (sNfl) levels in patients with MG longitudinally for up to 3 years. Based on linear regression, differences between patients and controls were assessed. With correlation coefficients and mixed linear regression, the association among sNfl levels, socio-demographics, disease activity (Quantitative Myasthenia Gravis (QMG) score and Myasthenia Gra

SUBMITTER: Stascheit F 

PROVIDER: S-EPMC9875128 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature