Circ_0099630 Participates in SPRY1-Mediated Repression in Periodontitis

ABSTRACT: Highlights • Upregulation of circ_0099630 was obtained in iPDLCs.• Forced circ_0099630 expression restrained iPDLC proliferation and osteogenic differentiation.• Circ_0099630 repressed iPDLC proliferation and osteogenic differentiation through the miR-212-5p/SPRY1 axis.

Background

Periodontitis is chronic inflammation that causes damage to periodontal tissues and cementum. It has been reported that circular RNA hsa_circ_0099630 (circ_0099630) was overexpressed in gingival samples from patients with periodontitis. However, the function of circ_0099630 on the osteogenic differentiation of periodontal ligament cells (PDLCs) in periodontitis remains unclear.

Methods

Periodontal ligaments from patients with periodontitis and third molars (termed wisdom teeth) were utilised to

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PROVIDER: S-EPMC9875226 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature