Five-year performance analysis of a cystic fibrosis newborn screening program in northeastern Brazil.

ABSTRACT:

Objective

To analyze the performance of the cystic fibrosis (CF) newborn screening (NBS) program over its first five years in a Brazilian northeastern state.

Method

A population-based study using a screening algorithm based on immunoreactive trypsinogen (IRT)/IRT. Data were retrieved from the state referral screening center registry. The program performance was evaluated using descriptive indicators such as the results of an active search, coverage, newborn's age at the time of blood sampling, the time between sample collection and its arrival at the laboratory, and the child's age at diagnosis of disease.

Results

The public CF screening program covered 82.6% of the 1,017,576 births that occurred, with an accumulated five-year incidence of 1:20,767 live births. The me

SUBMITTER: Godoy C 

PROVIDER: S-EPMC9875232 | biostudies-literature | 2023 Jan-Feb

REPOSITORIES: biostudies-literature