Increased rates of brain protein synthesis during [N1,N2] sleep: L-[1-¹¹C]leucine PET studies in human subjects.

ABSTRACT: During sleep, reduced brain energy demands provide an opportunity for biosynthetic processes like protein synthesis. Sleep is required for some forms of memory consolidation which requires de novo protein synthesis. We measured regional cerebral protein synthesis rates (rCPS) in human subjects to ascertain how rCPS is affected during sleep. Subjects underwent three consecutive L-[1-¹¹C]leucine PET scans with simultaneous polysomnography: 1. rested awake, 2. sleep-deprived awake, 3. sleep. Measured rCPS were similar across the three conditions. Variations in sleep stage times during sleep scans were used to estimate rCPS in sleep stages under the assumption that measured rCPS is the weighted sum of rCPS in each stage, with weights reflecting time and availability of [

SUBMITTER: Picchioni D 

PROVIDER: S-EPMC9875345 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature