Defining biomarkers in oral cancer according to smoking and drinking status.

ABSTRACT:

Introduction

Oral Squamous Cell Carcinomas (OSCC) are mostly related to tobacco consumption eventually associated to alcohol (Smoker/Drinker patients: SD), but 25-30% of the patients have no identified risk factors (Non-Smoker/Non-Drinker patients: NSND). We hypothesized that these patients have distinguishable immune profiles that could be useful for prognosis.

Materials and methods

Cells present in immune tumor microenvironment (TME) and blood from 87 OSCC HPV-negative patients were analyzed using a multiparameter flow cytometry assay, in a prospective case-control study. Cytokine levels in tumor supernatants and blood were determined by a cytometric bead array (CBA) assay.

Results

Normal gingiva and blood from healthy donors (HD) were used as controls. A significan

SUBMITTER: Rochefort J 

PROVIDER: S-EPMC9875375 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature