MYEOV overexpression induced by demethylation of its promoter contributes to pancreatic cancer progression via activation of the folate cycle/c-Myc/mTORC1 pathway.

ABSTRACT:

Background

While molecular targeted drugs and other therapies are being developed for many tumors, pancreatic cancer is still considered to be the malignant tumor with the worst prognosis. We started this study to identify prognostic genes and therapeutic targets of pancreatic cancer.

Methods

To comprehensively identify prognostic genes in pancreatic cancer, we investigated the correlation between gene expression and cancer-specific prognosis using transcriptome and clinical information datasets from The Cancer Genome Atlas (TCGA). In addition, we examined the effects of the suppression of candidate prognostic genes in pancreatic cancer cell lines.

Result

We found that patients with high expression levels of MYEOV, a primate-specific gene with unknown function, had si

SUBMITTER: Tange S 

PROVIDER: S-EPMC9875418 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature