Transfer of mesenchymal stem cell mitochondria to CD4⁺ T cells contributes to repress Th1 differentiation by downregulating T-bet expression.

ABSTRACT:

Background

Mesenchymal stem/stromal cells (MSCs) are multipotent cells with strong tissue repair and immunomodulatory properties. Due to their ability to repress pathogenic immune responses, and in particular T cell responses, they show therapeutic potential for the treatment of autoimmune diseases, organ rejection and graft versus host disease. MSCs have the remarkable ability to export their own mitochondria to neighboring cells in response to injury and inflammation. However, whether mitochondrial transfer occurs and has any role in the repression of CD4⁺ Th1 responses is unknown.

Methods and results

In this report we have utilized CD4⁺ T cells from HNT TCR transgenic mice that develop Th1-like responses upon antigenic stimulation in vitro and in viv

SUBMITTER: Akhter W 

PROVIDER: S-EPMC9875419 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature