Distinct COPD subtypes in former smokers revealed by gene network perturbation analysis.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) varies significantly in symptomatic and physiologic presentation. Identifying disease subtypes from molecular data, collected from easily accessible blood samples, can help stratify patients and guide disease management and treatment.

Methods

Blood gene expression measured by RNA-sequencing in the COPDGene Study was analyzed using a network perturbation analysis method. Each COPD sample was compared against a learned reference gene network to determine the part that is deregulated. Gene deregulation values were used to cluster the disease samples.

Results

The discovery set included 617 former smokers from COPDGene. Four distinct gene network subtypes are identified with significant differences in symptoms, exerci

SUBMITTER: Buschur KL 

PROVIDER: S-EPMC9875487 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature