Responsiveness to pulmonary rehabilitation in COPD is associated with changes in microbiota.

ABSTRACT:

Background

Pulmonary Rehabilitation (PR) is one of the most cost-effective therapies for chronic obstructive pulmonary disease (COPD) management. There are, however, people who do not respond to PR and reasons for non-response are mostly unknown. PR is likely to change the airway microbiota and this could play a role in its responsiveness. In this study we have explored the association between PR effectiveness and specific alterations in oral microbiota and inflammation.

Methods

A prospective longitudinal study was conducted. Data on exercise capacity, dyspnoea, impact of disease and 418 saliva samples were collected from 76 patients, half of whom participated in a 12-weeks PR programme. Responders and non-responders to PR (dyspnoea, exercise-capacity and impact of disease)

SUBMITTER: Melo-Dias S 

PROVIDER: S-EPMC9875510 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature